Toward Erobotics: An Investigation of the Relationships Between Stigma, Personality, Sexual Arousal, and Willingness to Engage Erotically with Robots

The rise of erobots (erôs + bots)—artificial erotic agents, such as sex robots—offers new opportunities for intimate experiences with machines. Their advent has also polarized academic and public debates: some denounce their risks, while others defend their benefits. Yet, the scientific study of human–machine erotic interaction and co-evolution remains limited: it lacks comprehensive theoretical models, and its empirical literature is scarce and fragmented. There is a need for a new, unified transdisciplinary field of research focusing on such phenomena, and guiding the development of beneficial technologies. We call this field erobotics. As a theoretical contribution to this new discipline, Chapter 2 defines erobotics and its related concepts, proposes a model of human-erobot interaction and co-evolution, and suggests a path to design beneficial erotic machines. As an empirical contribution to erobotics, this thesis examines some of the sociocultural, individual, and situational factors highlighted by this model. Specifically, it investigates the relationships between perceived stigma, personality traits, sexual arousal, and people’s willingness to engage erotically with robots. Chapter 3 shows that stigma related to erotic technology exists and increases as a function of products’ human-likeness. Chapter 4 shows that the willingness to engage with and perceived appropriateness of using sex robots more closely relate to erotophilia and sexual sensation seeking, rather than technophilia, non-sexual sensation seeking, and Big-Five traits. Chapter 5 shows that sexual arousal increases willingness to have sex with robots. In these three chapters, men were more interested in engaging erotically with robots than women. Together, these findings suggest that erotophilic sensation seekers—especially, men—may become the primary users of erobots, and that sexually aroused individuals may be more willing to engage erotically with such machines: potentially influencing their design and our relationship with them. Ultimately, this thesis founds erobotics and opens future directions for the study of human-machine erotic interaction and co-evolution

Skyrmions from a Born-Infeld Action

We consider a geometrically motivated Skyrme model based on a general covariant kinetic term proposed originally by Born and Infeld. We introduce this new term by generalizing the Born-Infeld action to a non-abelian $SU(2)$ gauge theory and by using the hidden gauge symmetry formalism. The static properties of the Skyrmion are then analyzed and compared with other Skyrme-like models.Comment: 11 pages, 4 figures (not included), revtex v3, LAVAL-PHY-11-9

Structural preferential attachment: Network organization beyond the link

We introduce a mechanism which models the emergence of the universal properties of complex networks, such as scale independence, modularity and self-similarity, and unifies them under a scale-free organization beyond the link. This brings a new perspective on network organization where communities, instead of links, are the fundamental building blocks of complex systems. We show how our simple model can reproduce social and information networks by predicting their community structure and more importantly, how their nodes or communities are interconnected, often in a self-similar manner.Comment: 4 pages, 3 figures, 1 tabl

Biomarkers of dementia in obstructive sleep apnea

Epidemiologic and mechanistic evidence is increasingly supporting the notion that obstructive sleep apnea is a risk factor for dementia. Hence, the identification of patients at risk of cognitive decline due to obstructive sleep apnea may significantly improve preventive strategies and treatment decisionmaking. Cerebrospinal fluid and blood biomarkers obtained through genomic, proteomic and metabolomic approaches are improving the ability to predict incident dementia. Therefore, fluid biomarkers have the potential to predict vulnerability to neurodegeneration in individuals with obstructive sleep apnea, as well as deepen our understanding of pathophysiological processes linking obstructive sleep apnea and dementia. Many fluid biomarkers linked to Alzheimer’s disease and vascular dementia show abnormal levels in individuals with obstructive sleep apnea, suggesting that these conditions share common underlying mechanisms, including amyloid and tau protein neuropathology, inflammation, oxidative stress, and metabolic disturbances. Markers of these processes include amyloid-β, tau proteins, inflammatory cytokines, acute-phase proteins, antioxydants and oxidized products, homocysteine and clusterin (apolipoprotein J). Thus, these biomarkers may have the ability to identify adults with obstructive sleep apnea at high risk of dementia and provide an opportunity for therapeutic intervention. Large cohort studies are necessary to establish a specific fluid biomarker panel linking obstructive sleep apnea to dementia risk

Paternal age explains a major portion of de novo germline mutation rate variability in healthy individuals

De novo mutations (DNM) are an important source of rare variants and are increasingly being linked to the development of many diseases. Recently, the paternal age effect has been the focus of a number of studies that attempt to explain the observation that increasing paternal age increases the risk for a number of diseases. Using disease-free familial quartets we show that there is a strong positive correlation between paternal age and germline DNM in healthy subjects. We also observed that germline CNVs do not follow the same trend, suggesting a different mechanism. Finally, we observed that DNM were not evenly distributed across the genome, which adds support to the existence of DNM hotspots

Exploring psychological mechanisms of collective action: Does relevance of group identity influence how people cope with collective disadvantage?

Two studies examined how the relevance of group identity influences two psychological mechanisms of collective action: Emotion- and problem-focused coping with collective disadvantage. Extending Van Zomeren, Spears, Fischer, and Leach's (2004) integrative theoretical model of coping with collective disadvantage, we predicted that when group identity is more relevant to disadvantaged group members, it increases their collective action tendencies through their feelings of group-based anger about their group's disadvantage. When group identity is less relevant and hence emotion-focused coping processes are less likely, group-efficacy beliefs become more predictive of disadvantaged group members' collective action tendencies because people focus more instrumentally on whether collective action will be effective (and benefit them) or not. A field study and a follow-up experiment both showed that the relevance of group identity facilitated emotion-focused coping and moderated problem-focused coping with collective disadvantage. We discuss these results in terms of two distinct psychological mechanisms of collective action

Pharmacogenomics of the efficacy and safety of Colchicine in COLCOT

© 2021 The Authors. Circulation: Genomic and Precision Medicine is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited and is not used for commercial purposes.Background: The randomized, placebo-controlled COLCOT (Colchicine Cardiovascular Outcomes Trial) has shown the benefits of colchicine 0.5 mg daily to lower the rate of ischemic cardiovascular events in patients with a recent myocardial infarction. Here, we conducted a post hoc pharmacogenomic study of COLCOT with the aim to identify genetic predictors of the efficacy and safety of treatment with colchicine. Methods: There were 1522 participants of European ancestry from the COLCOT trial available for the pharmacogenomic study of COLCOT trial. The pharmacogenomic study's primary cardiovascular end point was defined as for the main trial, as time to first occurrence of cardiovascular death, resuscitated cardiac arrest, myocardial infarction, stroke, or urgent hospitalization for angina requiring coronary revascularization. The safety end point was time to the first report of gastrointestinal events. Patients' DNA was genotyped using the Illumina Global Screening array followed by imputation. We performed a genome-wide association study in colchicine-treated patients. Results: None of the genetic variants passed the genome-wide association study significance threshold for the primary cardiovascular end point conducted in 702 patients in the colchicine arm who were compliant to medication. The genome-wide association study for gastrointestinal events was conducted in all 767 patients in the colchicine arm and found 2 significant association signals, one with lead variant rs6916345 (hazard ratio, 1.89 [95% CI, 1.52-2.35], P=7.41×10-9) in a locus which colocalizes with Crohn disease, and one with lead variant rs74795203 (hazard ratio, 2.51 [95% CI, 1.82-3.47]; P=2.70×10-8), an intronic variant in gene SEPHS1. The interaction terms between the genetic variants and treatment with colchicine versus placebo were significant. Conclusions: We found 2 genomic regions associated with gastrointestinal events in patients treated with colchicine. Those findings will benefit from replication to confirm that some patients may have genetic predispositions to lower tolerability of treatment with colchicine.info:eu-repo/semantics/publishedVersio